Tisagenlecleucel CAR T-cell therapy in secondary CNS lymphoma.
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ABSTRACT:
SUBMITTER: Frigault MJ
PROVIDER: S-EPMC7022436 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Tisagenlecleucel CAR T-cell therapy in secondary CNS lymphoma.
Frigault Matthew J MJ Dietrich Jorg J Martinez-Lage Maria M Leick Mark M Choi Bryan D BD DeFilipp Zachariah Z Chen Yi-Bin YB Abramson Jeremy J Crombie Jennifer J Armand Philippe P Nayak Lakshmi L Panzini Chris C Riley Lauren S LS Gallagher Kathleen K Maus Marcela V MV
Blood 20190718 11
Chimeric antigen receptor (CAR) T cells targeting CD19 have emerged as a leading engineered T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma. The phase 1/2 clinical trials that led to US Food and Drug Administration approval excluded patients with central nervous system (CNS) involvement, due to strict eligibility criteria. Here, we report on our institutional experience with 8 secondary CNS lymphoma patients treated with commercial tisagenlecleucel. No patient experienced grea ...[more]
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