Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC7022679 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Yang Hobin H Park Hayeon H Lee Yong Jin YJ Choi Jun Young JY Kim TaeEun T Rajasekaran Nirmal N Lee Saehyung S Song Kyoung K Hong Sungyoul S Choi Joon-Seok JS Shim Hyunbo H Kim Young-Deug YD Hwang Soohyun S Choi Yoon-La YL Shin Young Kee YK
Biomolecules 20191228 1
Most malignant tumors originate from epithelial tissues in which tight junctions mediate cell-cell interactions. Tight junction proteins, especially claudin-3 (CLDN3), are overexpressed in various cancers. Claudin-3 is exposed externally during tumorigenesis making it a potential biomarker and therapeutic target. However, the development of antibodies against specific CLDN proteins is difficult, because CLDNs are four-transmembrane domain proteins with high homology among CLDN family members and ...[more]