Ontology highlight
ABSTRACT:
SUBMITTER: Riva G
PROVIDER: S-EPMC7023031 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Microorganisms 20191220 1
In the last decades, the human papillomavirus (HPV) emerged as an etiological cause of head and neck squamous cell carcinoma (HNSCC), especially in the oropharynx. The role of two intracellular DNA sensors, which belong to the PYHIN family (interferon-inducible protein 16 (IFI16) and absent in melanoma 2 protein (AIM2)), has been analyzed in relation to HPV infection and head and neck carcinogenesis. In particular, IFI16 and AIM2 expression depends on HPV infection in HNSCC. They represent viral ...[more]