Ontology highlight
ABSTRACT:
SUBMITTER: Liutkute M
PROVIDER: S-EPMC7023365 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Liutkute Marija M Samatova Ekaterina E Rodnina Marina V MV
Biomolecules 20200107 1
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways. In this review, we summarize the recent examples of how translation affects folding of single-domain, multiple-domain and oligomeric proteins. The vectorial nature of translation, the spatial constraints of the exit tunnel, and the electrostatic ...[more]