Dataset Information

A Robust, Tough and Multifunctional Polyurethane/Tannic Acid Hydrogel Fabricated by Physical-Chemical Dual Crosslinking.

ABSTRACT: Commonly synthetic polyethylene glycol polyurethane (PEG-PU) hydrogels possess poor mechanical properties, such as robustness and toughness, which limits their load-bearing application. Hence, it remains a challenge to prepare PEG-PU hydrogels with excellent mechanical properties. Herein, a novel double-crosslinked (DC) PEG-PU hydrogel was fabricated by combining chemical with physical crosslinking, where trimethylolpropane (TMP) was used as the first chemical crosslinker and polyphenol compound tannic acid (TA) was introduced into the single crosslinked PU network by simple immersion process. The second physical crosslinking was formed by numerous hydrogen bonds between urethane groups of PU and phenol hydroxyl groups in TA, which can endow PEG-PU hydrogel with good mechanical properties, self-recovery and a self-healing capability. The research results indicated that as little as a 30 mg·mL-1 TA solution enhanced the tensile strength and fracture energy of PEG-PU hydrogel from 0.27 to 2.2 MPa, 2.0 to 9.6 KJ·m-2, respectively. Moreover, the DC PEG-PU hydrogel possessed good adhesiveness to diverse substrates because of TA abundant catechol groups. This work shows a simple and versatile method to prepare a multifunctional DC single network PEG-PU hydrogel with excellent mechanical properties, and is expected to facilitate developments in the biomedical field.

SUBMITTER: Wen J

PROVIDER: S-EPMC7023601 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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A Robust, Tough and Multifunctional Polyurethane/Tannic Acid Hydrogel Fabricated by Physical-Chemical Dual Crosslinking.

Wen Jie J Zhang Xiaopeng X Pan Mingwang M Yuan Jinfeng J Jia Zhanyu Z Zhu Lei L

Polymers 20200119 1

Commonly synthetic polyethylene glycol polyurethane (PEG-PU) hydrogels possess poor mechanical properties, such as robustness and toughness, which limits their load-bearing application. Hence, it remains a challenge to prepare PEG-PU hydrogels with excellent mechanical properties. Herein, a novel double-crosslinked (DC) PEG-PU hydrogel was fabricated by combining chemical with physical crosslinking, where trimethylolpropane (TMP) was used as the first chemical crosslinker and polyphenol compound ...[more]

PMID: 31963956

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Project description:Bacterial infection, tissue hypoxia and inflammatory response can hinder the infected wound repair process. To mitigate the above issues, tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets (MoS2@TA/Fe NSs) with dual enzyme activities were developed and anchored to a multifunctional hydrogel. The hydrogel exhibited excellent antibacterial ability owing to the combined effects of photothermal therapy (PTT), glutathione (GSH) loss, and the peroxidase (POD)-like activity (catalyse H2O2 into ·OH under acid condition) of MoS2@TA/Fe NSs. Benefitting from the catalase (CAT)-like activity, the hydrogel could decompose H2O2 into O2 at neutral pH to relieve hypoxia and supply adequate O2. POD-like activity was mainly attributed to MoS2 NSs, while CAT-like activity was primarily due to TA/Fe complex. Moreover, MoS2@TA/Fe NSs endowed the hydrogel with outstanding anti-oxidant ability to scavenge redundant reactive oxygen species (ROS) and reactive nitrogen species (RNS) under neutral environment to maintain the balance of antioxidant systems and prevent inflammation. In addition, the hydrogel could inhibit the release of inflammatory factors for the anti-inflammatory property of TA. TA retained partial phenolic hydroxyl groups, which cross-linked the nanosheets to the network structure of the hydrogel and promoted the adhesion of hydrogels. Due to the dynamic boron ester bonds between polyvinyl alcohol (PVA), dextran (Dex), MoS2@TA/Fe, and borax, the hydrogel demonstrated fast self-healing and rapid shape adaptability. This shape-adaptable adhesive hydrogel could fill the whole wound and closely contact the wound, ensuring that it achieved its functions with maximum efficiency. The MoS2@TA/Fe nanozyme-anchored multifunctional hydrogel showed high potential for bacteria-infected wound healing. Graphical abstract Image 1 Highlights • MoS2@TA/Fe NSs presents POD- and CAT-like activities.• MoS2@TA/Fe NSs shows anti-oxidant and anti-inflammation abilities.• The hydrogel shows fast self-healing, adhesiveness, and rapid shape-adaptivity.• MoS2@TA/Fe NSs-based hydrogel exhibits large potential in infected wound healing.

Dataset Information

A Robust, Tough and Multifunctional Polyurethane/Tannic Acid Hydrogel Fabricated by Physical-Chemical Dual Crosslinking.

Publications

A Robust, Tough and Multifunctional Polyurethane/Tannic Acid Hydrogel Fabricated by Physical-Chemical Dual Crosslinking.

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