Dataset Information

Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation.

ABSTRACT:

Introduction/purpose

Limited studies have examined the association of physical activity with reproductive hormones, DNA methylation, and pubertal status among adolescents.

Methods

Among 248 boys and 271 girls, we estimated daily physical activity levels based on 7 d of wrist-worn accelerometer data. We used an isotemporal substitution paradigm and sex-stratified regression models to examine the association of physical activity levels with 1) testosterone, cortisol, progesterone, and androstenedione concentrations; 2) DNA methylation of long interspersed nucleotide (LINE-1) repeats and the genes H19, hydroxysteroid (11-Beta) dehydrogenase 2 (HSD11B2), and peroxisome proliferator-activated receptor alpha (PPARA) from blood leukocytes; and 3) Tanner stages, adjusted for age, BMI, and socioeconomic status.

Results

In boys, substituting 30 min of moderate physical activity for 30 min of sedentary behavior per day was associated with 29% (-49%, 0%) of lower testosterone and 29% (4%, 61%) of higher progesterone. Substituting 30 min of light physical activity for sedentary behavior was associated with 13% (-22%, -2%) of lower progesterone. Among girls, 30 min of additional sedentary behavior was associated with 8% (-15%, 0%) of lower testosterone and 24% (8%, 42%) of higher progesterone concentrations. Substituting 30 min of moderate physical activity for sedentary behavior was associated with 15% (0%, 31%) of higher cortisol, whereas substituting the same amount of light physical activity for sedentary behavior was associated with 22% (-39%, 0%) of lower progesterone. Substituting 30 min of vigorous physical activity for sedentary behavior per day was associated with almost six times higher levels (5.83, 95% confidence interval = 1.79-9.86) of HSD11B2 methylation in boys.

Conclusions

Accelerometer-measured daily physical activity was associated with reproductive hormones and HSD11B2 DNA methylation, differed by sex and activity intensity levels.

SUBMITTER: Wu Y

PROVIDER: S-EPMC7024035 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation.

Wu Yue Y Goodrich Jaclyn M JM Dolinoy Dana C DC Sánchez Brisa N BN Ruiz-Narváez Edward A EA Banker Margaret M Cantoral Alejandra A Mercado-Garcia Adriana A Téllez-Rojo Martha M MM Peterson Karen E KE

Medicine and science in sports and exercise 20200301 3

<h4>Introduction/purpose</h4>Limited studies have examined the association of physical activity with reproductive hormones, DNA methylation, and pubertal status among adolescents.<h4>Methods</h4>Among 248 boys and 271 girls, we estimated daily physical activity levels based on 7 d of wrist-worn accelerometer data. We used an isotemporal substitution paradigm and sex-stratified regression models to examine the association of physical activity levels with 1) testosterone, cortisol, progesterone, a ...[more]

PMID: 31652236

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Dataset Information

Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation.

Introduction/purpose

Methods

Results

Conclusions

Publications

Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation.

Similar Datasets

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