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Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius.

ABSTRACT: Eight new (1-8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC50 values 15 and 16 ?M, respectively.

SUBMITTER: Smyrniotopoulos V

PROVIDER: S-EPMC7024270 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius.

Smyrniotopoulos Vangelis V de Andrade Tomaz Anna Cláudia AC Vanderlei de Souza Maria de Fátima MF Leitão da Cunha Emídio Vasconcelos EV Kiss Robert R Mathieu Véronique V Ioannou Efstathia E Roussis Vassilios V

Marine drugs 20191229 1

Eight new (1-8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 an ...[more]

PMID: 31905719

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