Unknown

Dataset Information

0

Limitations of 6-minute walk test reference values for spinal muscular atrophy.

ABSTRACT: INTRODUCTION:The 6-minute walk test (6MWT) is a well-established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease-modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls. METHODS:The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values. RESULTS:Three pediatric and six adult studies were selected for comparison. The % predicted values using the pediatric and adult equations ranged from 47.7?±?18.2% to 67.6?±?26.2% and 43.0?±?17.9% to 59.5?±?26.2%, respectively, and were significantly different (P?

SUBMITTER: Goodwin AM 

PROVIDER: S-EPMC7024648 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Limitations of 6-minute walk test reference values for spinal muscular atrophy.

Goodwin Ashley M AM   Cornett Kayla M D KMD   McKay Marnee J MJ   Burns Joshua J   Garber Carol Ewing CE   De Vivo Darryl C DC   Montes Jacqueline J  

Muscle & nerve 20200116 3

<h4>Introduction</h4>The 6-minute walk test (6MWT) is a well-established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease-modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls.<h4>Methods</h4>The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Th  ...[more]

Similar Datasets

Unknown Six-Minute Walk Test demonstrates motor fatigue in spinal muscular atrophy.
| S-EPMC2839195 | biostudies-literature
Unknown Two-minute versus 6-minute walk distances during 6-minute walk test in neuromuscular disease: Is the 2-minute walk test an effective alternative to a 6-minute walk test?
| S-EPMC6423958 | biostudies-literature
Unknown Two-minute walk test: Reference equations for healthy adults in China.
| S-EPMC6085060 | biostudies-literature
Unknown Advances and limitations for the treatment of spinal muscular atrophy.
| S-EPMC9632131 | biostudies-literature
Unknown Six minute walk distance and reference values in healthy Italian children: A cross-sectional study.
| S-EPMC6188863 | biostudies-literature
Unknown Developing a Natural History Progression Model for Duchenne Muscular Dystrophy Using the Six-Minute Walk Test.
| S-EPMC5613187 | biostudies-literature
Unknown Spinal muscular atrophy.
| S-EPMC4514700 | biostudies-other
Unknown Validity and reliability of the 2-minute walk test in individuals with spinal cord injury.
| S-EPMC9836932 | biostudies-literature
Unknown Knowledge of genetic test results among caregivers and individuals with spinal muscular atrophy.
| S-EPMC9642888 | biostudies-literature
Unknown Motor Function Test Reliability During the NeuroNEXT Spinal Muscular Atrophy Infant Biomarker Study.
| S-EPMC8112280 | biostudies-literature