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Limitations of 6-minute walk test reference values for spinal muscular atrophy.

ABSTRACT: INTRODUCTION:The 6-minute walk test (6MWT) is a well-established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease-modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls. METHODS:The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values. RESULTS:Three pediatric and six adult studies were selected for comparison. The % predicted values using the pediatric and adult equations ranged from 47.7?±?18.2% to 67.6?±?26.2% and 43.0?±?17.9% to 59.5?±?26.2%, respectively, and were significantly different (P?

SUBMITTER: Goodwin AM 

PROVIDER: S-EPMC7024648 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Limitations of 6-minute walk test reference values for spinal muscular atrophy.

Goodwin Ashley M AM   Cornett Kayla M D KMD   McKay Marnee J MJ   Burns Joshua J   Garber Carol Ewing CE   De Vivo Darryl C DC   Montes Jacqueline J  

Muscle & nerve 20200116 3

<h4>Introduction</h4>The 6-minute walk test (6MWT) is a well-established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease-modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls.<h4>Methods</h4>The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Th  ...[more]

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