Ontology highlight
ABSTRACT:
SUBMITTER: Shen D
PROVIDER: S-EPMC7025326 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Shen Deliang D Li Zhenhua Z Hu Shiqi S Huang Ke K Su Teng T Liang Hongxia H Liu Feiran F Cheng Ke K
Nano letters 20190218 3
Stem cell therapies have shown promise in treating acute and chronic ischemic heart disease. However, current therapies are limited by the low retention and poor integration of injected cells in the injured tissue. Taking advantage of the natural infarct-homing ability of platelets, we engineered CD34 antibody-linked platelets (P-CD34) to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart. In vitro, P-CD34 could bind to damaged aortas and capture endogen ...[more]