Ontology highlight
ABSTRACT:
SUBMITTER: Yukawa T
PROVIDER: S-EPMC7025387 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yukawa Tomoya T Naven Russell R
ACS medicinal chemistry letters 20200129 2
The role that physicochemical properties play toward increasing the likelihood of toxicity findings in <i>in vivo</i> studies has been well reported, albeit sometimes with different conclusions. We decided to understand the role that physicochemical properties play toward the prediction of <i>in vivo</i> toxicological outcomes for Takeda chemistry using 284 internal compounds. In support of the previously reported "3/75 rule", reducing lipophilicity of molecules decreases toxicity odds noticeabl ...[more]