Ontology highlight
ABSTRACT:
SUBMITTER: DuBuc TQ
PROVIDER: S-EPMC7025884 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
DuBuc Timothy Q TQ Schnitzler Christine E CE Chrysostomou Eleni E McMahon Emma T ET Febrimarsa Gahan James M JM Buggie Tara T Gornik Sebastian G SG Hanley Shirley S Barreira Sofia N SN Gonzalez Paul P Baxevanis Andreas D AD Frank Uri U
Science (New York, N.Y.) 20200201 6479
Clonal animals do not sequester a germ line during embryogenesis. Instead, they have adult stem cells that contribute to somatic tissues or gametes. How germ fate is induced in these animals, and whether this process is related to bilaterian embryonic germline induction, is unknown. We show that transcription factor AP2 (Tfap2), a regulator of mammalian germ lines, acts to commit adult stem cells, known as i-cells, to the germ cell fate in the clonal cnidarian <i>Hydractinia symbiolongicarpus</i ...[more]