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Insights into CD47/SIRPα axis-targeting tumor immunotherapy.

ABSTRACT: During the last decade, inhibitors targeting immune checkpoint programmed death ligand 1/PD-1 and cytotoxic T-lymphocyte-associated protein 4 have been one of the most significant advances for cancer therapy in clinic. However, most of these therapies focused on stimulating the adaptive immune system-mediated elimination of tumor. Recent studies indicated that CD47/Signal-regulatory protein alpha (SIRPα), an innate anti-phagocytic axis between cancer cells and macrophages, could be a promising therapeutic target. Here, we review the current knowledge about developing CD47/SIRPα checkpoint inhibitors, avoiding potential side effect and designing optimal combination therapies, and highlight the key points for future clinical applications of CD47/SIRPα axis-targeted tumor immunotherapy.

SUBMITTER: Zhang X

PROVIDER: S-EPMC8157794 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Insights into CD47/SIRPα axis-targeting tumor immunotherapy.

Zhang Xuyao X Fan Jiajun J Ju Dianwen D

Antibody therapeutics 20180828 2

During the last decade, inhibitors targeting immune checkpoint programmed death ligand 1/PD-1 and cytotoxic T-lymphocyte-associated protein 4 have been one of the most significant advances for cancer therapy in clinic. However, most of these therapies focused on stimulating the adaptive immune system-mediated elimination of tumor. Recent studies indicated that CD47/Signal-regulatory protein alpha (SIRP<b>α</b>), an innate anti-phagocytic axis between cancer cells and macrophages, could be a prom ...[more]

PMID: 34056543

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