Ontology highlight
ABSTRACT:
SUBMITTER: Gierisch ME
PROVIDER: S-EPMC7026131 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Gierisch Maria E ME Giovannucci Tatiana A TA Dantuma Nico P NP
Frontiers in chemistry 20200211
Instant and adequate handling of misfolded or otherwise aberrant proteins is of paramount importance for maintaining protein homeostasis in cells. The ubiquitin/proteasome system (UPS) is a central player in protein quality control as it operates in a seek-and-destroy mode, thereby facilitating elimination of faulty proteins. While proteasome inhibition is in clinical use for the treatment of hematopoietic malignancies, stimulation of the UPS has been proposed as a potential therapeutic strategy ...[more]