Poxvirus exploitation of the ubiquitin-proteasome system.
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ABSTRACT:
SUBMITTER: Barry M
PROVIDER: S-EPMC3185573 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Poxvirus exploitation of the ubiquitin-proteasome system.
Barry Michele M Van Buuren Nicholas N Burles Kristin K Mottet Kelly K Wang Qian Q Teale Alastair A
Viruses 20101019 10
Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been shown to encode BTB/kelch and ankyrin/F-box proteins that interact with cullin-3 and cullin-1 based ubiquitin ligases, respectively. Multiple members of the poxvirus family also encode ubiquitin ligases with intrinsic activity. This review descr ...[more]
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