Unknown

Dataset Information

0

Fzr/Cdh1 Promotes the Differentiation of Neural Stem Cell Lineages in Drosophila.


ABSTRACT: How stem cells and progenitors balance between self-renewal and differentiation is a central issue of stem cell biology. Here, we describe a novel and essential function of Drosophila Fzr/Cdh1, an evolutionary conserved protein, during the differentiation of neural stem cell (NSC) lineages in the central nervous system. We show that Fzr, a known co-activator of Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase, promotes the production of neurons from neural progenitors called ganglion mother cells (GMCs). However, knockdown of APC/C subunit Ida or another APC/C co-activator CDC20 does not similarly impair GMC-neuron transition. We also observe a concomitant loss of differentiation factor Prospero expression and ectopic accumulation of mitotic kinase Polo in fzr mutant clones, strongly supporting the impairment of GMC to neuron differentiation. Besides functioning in GMCs, Fzr is also present in NSCs to facilitate the production of intermediate neural progenitors from NSCs. Taken together, Fzr plays a novel function in promoting differentiation programs during Drosophila NSC lineage development. Given that human Fzr is inactivated in multiple types of human cancers including brain tumors and that Fzr regulates neurotoxicity in various models of neurodegenerative diseases, our study on the role of Fzr in turning off proliferation in neuronal cells may provide insights into how Fzr deficits may contribute to human neurodegenerative diseases and tumors.

SUBMITTER: Ly PT 

PROVIDER: S-EPMC7026481 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Fzr/Cdh1 Promotes the Differentiation of Neural Stem Cell Lineages in <i>Drosophila</i>.

Ly Phuong Thao PT   Wang Hongyan H  

Frontiers in cell and developmental biology 20200211


How stem cells and progenitors balance between self-renewal and differentiation is a central issue of stem cell biology. Here, we describe a novel and essential function of <i>Drosophila</i> Fzr/Cdh1, an evolutionary conserved protein, during the differentiation of neural stem cell (NSC) lineages in the central nervous system. We show that Fzr, a known co-activator of Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase, promotes the production of neurons from neural progenitors called  ...[more]

Similar Datasets

| S-EPMC8081629 | biostudies-literature
| S-EPMC5688236 | biostudies-literature
| S-EPMC7055365 | biostudies-literature
| S-EPMC5690824 | biostudies-literature
| S-EPMC6393469 | biostudies-literature
| S-EPMC6827381 | biostudies-literature
| S-EPMC5207321 | biostudies-literature
| S-EPMC5225046 | biostudies-literature
| S-EPMC7408363 | biostudies-literature
| S-EPMC5233403 | biostudies-literature