Ontology highlight
ABSTRACT:
SUBMITTER: Weber U
PROVIDER: S-EPMC5225046 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Developmental cell 20161229 1
The Anaphase-Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase, well known for its role in cell-cycle progression. However, it has been linked to additional functions, mainly in neuronal contexts, when using the co-activator Cdh1/Fzr. Here, our data indicate a post-mitotic requirement for the APC/C<sup>Fzr/Cdh1</sup> in epithelial cell patterning and planar cell polarity (PCP) in Drosophila. PCP signaling is critical for development by establishing cellular asymmetries and orientatio ...[more]