Ontology highlight
ABSTRACT:
SUBMITTER: Dave A
PROVIDER: S-EPMC7026635 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Davé Anoushka A Pai Chen-Chun CC Durley Samuel C SC Hulme Lydia L Sarkar Sovan S Wee Boon-Yu BY Prudden John J Tinline-Purvis Helen H Cullen Jason K JK Walker Carol C Watson Adam A Carr Antony M AM Murray Johanne M JM Humphrey Timothy C TC
Nucleic acids research 20200201 3
The healing of broken chromosomes by de novo telomere addition, while a normal developmental process in some organisms, has the potential to cause extensive loss of heterozygosity, genetic disease, or cell death. However, it is unclear how de novo telomere addition (dnTA) is regulated at DNA double-strand breaks (DSBs). Here, using a non-essential minichromosome in fission yeast, we identify roles for the HR factors Rqh1 helicase, in concert with Rad55, in suppressing dnTA at or near a DSB. We f ...[more]