Ontology highlight
ABSTRACT:
SUBMITTER: Lepesant JMJ
PROVIDER: S-EPMC7026653 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Lepesant Julie M J JMJ Iampietro Carole C Galeota Eugenia E Augé Benoit B Aguirrenbengoa Marion M Mercé Clemèntine C Chaubet Camille C Rocher Vincent V Haenlin Marc M Waltzer Lucas L Pelizzola Mattia M Di Stefano Luisa L
Nucleic acids research 20200201 3
The histone demethylase LSD1 is a key chromatin regulator that is often deregulated in cancer. Its ortholog, dLsd1 plays a crucial role in Drosophila oogenesis; however, our knowledge of dLsd1 function is insufficient to explain its role in the ovary. Here, we have performed genome-wide analysis of dLsd1 binding in the ovary, and we document that dLsd1 is preferentially associated to the transcription start site of developmental genes. We uncovered an unanticipated interplay between dLsd1 and th ...[more]