Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration.

ABSTRACT: BACKGROUND:Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. METHODS:Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5?±?7.7?years; 22 men) and 20 control subjects (mean age: 62.9?±?14.0?years; 10 men), and d-ROMs and BAP tests were examined. RESULTS:In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0?±?52.4 vs. 275.1?±?45.5?U.CARR, respectively; P?

SUBMITTER: Matsuura T 

PROVIDER: S-EPMC7027115 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature