Unknown

Dataset Information

0

Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential.


ABSTRACT: There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure oxidative stress and antioxidant capacity at the same time or studies considering childhood development. Therefore, this study comprehensively assessed the level of oxidative stress in ASD children by simultaneously measuring reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). The subjects were Japanese, 77 typical development (TD) children, 98 ASD children, samples were plasma. The subjects were divided into age groups: toddlers/preschool age (2-6 years) and school age (7-15 years), to compare the relationships among the d-ROMs levels and BAP/d-ROMs ratios. Furthermore, the correlations between the Parent-interview ASD Rating Scales (PARS) scores and the measured values were analyzed. The levels of d-ROMs were significantly higher in the ASD (7-15 years) than in TD (7-15 years). The PARS scores were significantly higher in the ASD and were significantly correlated with d-ROMs levels. These results suggested that d-ROMs and BAP/d-ROMs ratios could be objective, measured indicators that could be used in clinical practice to assess stress in ASD children.

SUBMITTER: Morimoto M 

PROVIDER: S-EPMC7244111 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential.

Morimoto Masahito M   Hashimoto Toshiaki T   Tsuda Yoshimi Y   Nakatsu Tadanori T   Kitaoka Taisuke T   Kyotani Shojiro S  

PloS one 20200522 5


There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure oxidative stress and antioxidant capacity at the same time or studies considering childhood development. Therefore, this study comprehensively assessed the level of oxidative stress in ASD children by simultaneously measuring reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). The subjects were Japanese, 77 typical development (TD) children  ...[more]

Similar Datasets

| S-EPMC7183642 | biostudies-literature
| S-EPMC7027115 | biostudies-literature
| S-EPMC6921539 | biostudies-literature
2018-02-27 | GSE111176 | GEO
| S-EPMC8266874 | biostudies-literature
| S-EPMC8900942 | biostudies-literature
| S-EPMC7540056 | biostudies-literature
| S-EPMC8314997 | biostudies-literature
2021-10-01 | GSE164563 | GEO
2018-11-25 | E-MTAB-7351 | biostudies-arrayexpress