Long-term renal graft outcome after parathyroidectomy - a retrospective single centre study.

ABSTRACT: BACKGROUND:Surgical correction of hyperparathyroidism after kidney transplantation has been associated with significant graft function decline. We examined the effects of parathyroidectomy on short- and long-term graft function and its potential predictors. METHODS:For this retrospective, monocentric study we identified 48 (5.5%) out of 892 patients from our protocol biopsy program who received renal transplantation between 2000 and 2007, with parathyroidectomy after transplantation. Data from up to three years after parathyroidectomy was collected and analyzed with multivariable linear regression analyses. RESULTS:Main indications for parathyroidectomy were hypercalcemia and graft calcifications. Parathyroidectomy was successful in 47 patients, with a median drop in serum intact parathormone (iPTH) from 394 to 21?pg/ml. Mean estimated glomerular fitration rate (eGFR) before parathyroidectomy was 60?±?26?ml/min. At three months after parathyroidectomy, the eGFR was 46?±?18?ml/min (p?

SUBMITTER: Patecki M 

PROVIDER: S-EPMC7027287 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature