Enhancement of β-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing Na_V1.5 expression in mice.

ABSTRACT:

Background

β-Catenin/T-cell factor 4 (TCF4) signaling is enhanced in ischemic heart disease in which ventricular tachycardia (VT)/ventricular fibrillation occurs frequently. How this signaling links to arrhythmogenesis remains unclear.

Objective

The purpose of this study was to investigate the role of β-catenin gain of function in the development of arrhythmia.

Methods

A mouse model with a conditional deletion of CTNNB1 exon 3 resulting in cardiac exon 3-deleted and stabilized β-catenin (β-catΔE3) was used to determine the role of β-catenin gain of function in the regulation of cardiac rhythm.

Results

Western blotting showed β-catΔE3 expression and significantly decreased Na_V1.5 protein in CTNNB1 E3^-/- and CTNNB1 E3^+/- mouse hea

SUBMITTER: Huo R 

PROVIDER: S-EPMC7027965 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature