Ontology highlight
ABSTRACT:
SUBMITTER: Maisonial-Besset A
PROVIDER: S-EPMC9822305 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Maisonial-Besset Aurélie A Witkowski Tiffany T Quintana Mercedes M Besse Sophie S Gaumet Vincent V Cordonnier Axel A Alliot Cyrille C Vidal Aurélien A Denevault-Sabourin Caroline C Tarrit Sébastien S Levesque Sophie S Miot-Noirault Elisabeth E Chezal Jean-Michel JM
Molecules (Basel, Switzerland) 20221222 1
The development of <sup>64</sup>Cu-based immuno-PET radiotracers requires the use of copper-specific bifunctional chelators (BFCs) that contain functional groups allowing both convenient bioconjugation and stable copper complexes to limit in vivo bioreduction, transmetallation and/or transchelation. The excellent in vivo kinetic inertness of the pentaazamacrocyclic [<sup>64</sup>Cu]Cu-15-5 complex prompted us to investigate its potential for the <sup>64</sup>Cu-labelling of monoclonal antibodies ...[more]