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Photosensitized Intermolecular Carboimination of Alkenes through the Persistent Radical Effect.

ABSTRACT: An intermolecular, two-component vicinal carboimination of alkenes has been accomplished by energy transfer catalysis. Oxime esters of alkyl carboxylic acids were used as bifunctional reagents to generate both alkyl and iminyl radicals. Subsequently, addition of the alkyl radical to an alkene generates a transient radical for selective radical-radical cross-coupling with the persistent iminyl radical. Furthermore, this process provides direct access to aliphatic primary amines and ?-amino acids by simple hydrolysis.

SUBMITTER: Patra T

PROVIDER: S-EPMC7028066 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Photosensitized Intermolecular Carboimination of Alkenes through the Persistent Radical Effect.

Patra Tuhin T Bellotti Peter P Strieth-Kalthoff Felix F Glorius Frank F

Angewandte Chemie (International ed. in English) 20200121 8

An intermolecular, two-component vicinal carboimination of alkenes has been accomplished by energy transfer catalysis. Oxime esters of alkyl carboxylic acids were used as bifunctional reagents to generate both alkyl and iminyl radicals. Subsequently, addition of the alkyl radical to an alkene generates a transient radical for selective radical-radical cross-coupling with the persistent iminyl radical. Furthermore, this process provides direct access to aliphatic primary amines and α-amino acids ...[more]

PMID: 31794633

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