Ontology highlight
ABSTRACT:
SUBMITTER: Wang XJ
PROVIDER: S-EPMC7028908 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature communications 20200218 1
α-Synucleinopathies are characterized by autonomic dysfunction and motor impairments. In the pure autonomic failure (PAF), α-synuclein (α-Syn) pathology is confined within the autonomic nervous system with no motor features, but mouse models recapitulating PAF without motor dysfunction are lacking. Here, we show that in TgM83<sup>+/-</sup> mice, inoculation of α-Syn preformed fibrils (PFFs) into the stellate and celiac ganglia induces spreading of α-Syn pathology only through the autonomic pathw ...[more]