Ontology highlight
ABSTRACT:
SUBMITTER: Eduati F
PROVIDER: S-EPMC7029724 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Eduati Federica F Jaaks Patricia P Wappler Jessica J Cramer Thorsten T Merten Christoph A CA Garnett Mathew J MJ Saez-Rodriguez Julio J
Molecular systems biology 20200201 2
Mechanistic modeling of signaling pathways mediating patient-specific response to therapy can help to unveil resistance mechanisms and improve therapeutic strategies. Yet, creating such models for patients, in particular for solid malignancies, is challenging. A major hurdle to build these models is the limited material available that precludes the generation of large-scale perturbation data. Here, we present an approach that couples ex vivo high-throughput screenings of cancer biopsies using mi ...[more]