Ontology highlight
ABSTRACT:
SUBMITTER: Dietlein F
PROVIDER: S-EPMC7031046 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Dietlein Felix F Weghorn Donate D Taylor-Weiner Amaro A Richters André A Reardon Brendan B Liu David D Lander Eric S ES Van Allen Eliezer M EM Sunyaev Shamil R SR
Nature genetics 20200203 2
Cancer genomes contain large numbers of somatic mutations but few of these mutations drive tumor development. Current approaches either identify driver genes on the basis of mutational recurrence or approximate the functional consequences of nonsynonymous mutations by using bioinformatic scores. Passenger mutations are enriched in characteristic nucleotide contexts, whereas driver mutations occur in functional positions, which are not necessarily surrounded by a particular nucleotide context. We ...[more]