Ontology highlight
ABSTRACT:
SUBMITTER: Ichikawa K
PROVIDER: S-EPMC7031295 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Ichikawa Kenji K Watanabe Miyano Saori S Minoshima Yukinori Y Matsui Junji J Funahashi Yasuhiro Y
Scientific reports 20200219 1
Anti-vascular endothelial growth factor (VEGF) therapy shows antitumor activity against various types of solid cancers. Several resistance mechanisms against anti-VEGF therapy have been elucidated; however, little is known about the mechanisms by which the acquired resistance arises. Here, we developed new anti-VEGF therapy-resistant models driven by chronic expression of the mouse VEGFR2 extracellular domain fused with the human IgG4 fragment crystallizable (Fc) region (VEGFR2-Fc). In the VEGFR ...[more]