Osteoclasts are not a source of SLIT3.
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ABSTRACT:
SUBMITTER: Li N
PROVIDER: S-EPMC7031526 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Osteoclasts are not a source of SLIT3.
Li Na N Inoue Kazuki K Sun Jun J Niu Yingzhen Y Lalani Sarfaraz S Yallowitz Alisha A Yang Xu X Zhang Chao C Shen Rong R Zhao Baohong B Xu Ren R Greenblatt Matthew B MB
Bone research 20200219
The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent reports. However, these reports conflict in their nomination of osteoblasts versus osteoclasts as the key producers of skeletal SLIT3 and additionally offer conflicting data on the effects of SLIT3 on osteoclastogenesis. Here, aiming to address this discrepancy, we found no observable SLIT3 expression during human or mouse osteoclastogenesis and the only modest SLIT3-mediated effects on osteoclast differentiation. ...[more]
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