Long-term trends in myocardial sympathetic innervation and function in synucleinopathies.

ABSTRACT: INTRODUCTION:Parkinson disease (PD), pure autonomic failure (PAF), and multiple system atrophy (MSA) are characterized by intra-cerebral deposition of the protein alpha-synuclein and are termed synucleinopathies. Lewy body synucleinopathies involve decreased cardiac sympathetic innervation and functional abnormalities in residual noradrenergic terminals. This observational, retrospective, cohort study describes long-term trends in indices of cardiac sympathetic innervation and function in synucleinopathies. METHODS:Patients with PD (N?=?31), PAF (N?=?9), or MSA (N?=?9) underwent repeated 18F-dopamine positron emission tomography (median follow-up 3.5 years). Interventricular septal 18F-dopamine-derived radioactivity 8?min after tracer injection (8' Radioactivity) was used as an index of sympathetic innervation and the slope of mono-exponential decline of radioactivity between 8 and 25?min (k8'-25') as an index of intraneuronal vesicular storage. Healthy volunteers (HVs) (N?=?33) and individuals at high risk of PD (N?=?15) were controls. RESULTS:Upon initial evaluation the groups with PD and orthostatic hypotension (OH), PAF, or PD and no OH had low mean 8' Radioactivity compared to HVs (p?

SUBMITTER: Lamotte G 

PROVIDER: S-EPMC7031858 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature