Physicochemical properties of ?-cyclodextrin solutions and precipitates prepared from injectable vehicles.

ABSTRACT: ?-Cyclodextrin (?-CyD) is cyclic oligosaccharide of a glucopyranose, containing a relatively hydrophobic central cavity and hydrophilic outer surface. However, the usefulness of ?-CyD is limited owing to its low aqueous solubility whereas we found that its apparent high solubility was evident in some injectable solvents including 2-pyrrolidone (PYR), N-methyl pyrrolidone (NMP) and dimethyl sulfoxide (DMSO). Therefore, in the present study, the physicochemical properties of the 30-60% w/w ?-CyD in PYR, NMP and DMSO were investigated such as viscosity, water resistant, matrix formation rate and syringeability. The higher the concentration of ?-CyD resulted in the increased viscosity and the higher force and energy of syringeability. ?-CyD in PYR gave the highest viscosity which contributed to the lowest syringeability while ?-CyD in DMSO exhibited the highest syringeability. The ?-CyD in DMSO and NMP exhibited the higher rate of matrix formation. ?-CyD in PYR showed the highest water resistant for phase separation while ?-CyD in NMP gave the faster de-mixing rate compared to that from PYR. The difference in physicochemical properties of ?-CyD dried ppts studied by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA) revealed that there was partial complexation of ?-CyD with respective solvents. Both solution and precipitate characteristic properties will be useful for using ?-CyD in further investigation as matrix material dissolved in the injectable vehicles as the in situ forming gel for periodontitis treatment.

SUBMITTER: Thurein SM 

PROVIDER: S-EPMC7032148 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature