Ontology highlight
ABSTRACT:
SUBMITTER: Carrillo E
PROVIDER: S-EPMC7034100 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
The Journal of general physiology 20200101 1
Fast excitatory synaptic transmission in the mammalian central nervous system is mediated by glutamate-activated α-amino-5-methyl-3-hydroxy-4-isoxazole propionate (AMPA) receptors. In neurons, AMPA receptors coassemble with transmembrane AMPA receptor regulatory proteins (TARPs). Assembly with TARP γ8 alters the biophysical properties of the receptor, producing resensitization currents in the continued presence of glutamate. Using single-channel recordings, we show that under resensitizing condi ...[more]