Ontology highlight
ABSTRACT:
SUBMITTER: Reid S
PROVIDER: S-EPMC7034364 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Reid Sarah S Alexsson Andrei A Frodlund Martina M Morris David D Sandling Johanna K JK Bolin Karin K Svenungsson Elisabet E Jönsen Andreas A Bengtsson Christine C Gunnarsson Iva I Illescas Rodriguez Vera V Bengtsson Anders A Arve Sabine S Rantapää-Dahlqvist Solbritt S Eloranta Maija-Leena ML Syvänen Ann-Christine AC Sjöwall Christopher C Vyse Timothy James TJ Rönnblom Lars L Leonard Dag D
Annals of the rheumatic diseases 20191211 3
<h4>Objectives</h4>To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).<h4>Methods</h4>Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each individual based on 57 SLE risk loci.<h4>Results</h4>SLE was more prevalent in the hig ...[more]