Longitudinal disease- and steroid-related damage among adults with childhood-onset systemic lupus erythematosus.

ABSTRACT:

Objectives

Determine whether adults with childhood-onset systemic lupus erythematosus (cSLE) are at increased risk for disease- and steroid-related damage as compared to individuals with adult-onset SLE (aSLE), and whether they continue to accumulate disease damage in adulthood.

Methods

Data derive from the 2007-2015 cycles of the Lupus Outcomes Study, a longitudinal cohort of adults with confirmed SLE. The Brief Index of Lupus Damage (BILD), a validated, patient-reported measure, was used to assess SLE-associated damage. Participants with baseline BILD were included (N = 1035). Diagnosis at age < 18 years was defined as cSLE (N = 113). Outcome variables included BILD score at baseline and follow-up, clinically significant change in BILD score over follow-up period, and pres

SUBMITTER: Heshin-Bekenstein M 

PROVIDER: S-EPMC7480934 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature