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Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling.

ABSTRACT: A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-13/14C] alkyl amides, thereby reducing radioactive waste, and handling of radioactive materials. Easily accessible and low-cost equipment and a palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides.

SUBMITTER: Sardana M

PROVIDER: S-EPMC7034930 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Visible-Light-Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling.

Sardana Malvika M Bergman Joakim J Ericsson Cecilia C Kingston Lee P LP Schou Magnus M Dugave Christophe C Audisio Davide D Elmore Charles S CS

The Journal of organic chemistry 20191211 24

A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [<i>carbonyl</i>-<sup>13/14</sup>C] alkyl amides, thereby reducing radioactive waste, and handling of radioactive materials. Easily accessible and low-cost equipment and a palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides. ...[more]

PMID: 31769679

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