Ontology highlight
ABSTRACT:
SUBMITTER: Sargent BT
PROVIDER: S-EPMC7070179 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190605 28
Metal-catalyzed aminocarbonylation is a standard approach for installing amide functionality in chemical synthesis. Despite broad application of this transformation using aryl or vinyl electrophiles, there are few examples involving unactivated aliphatic substrates. Furthermore, there are no stereocontrolled aminocarbonylations of alkyl electrophiles known. Herein, we report a stereospecific aminocarbonylation of unactivated alkyl tosylates for the synthesis of enantioenriched amides. This cobal ...[more]