MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response.
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ABSTRACT:
SUBMITTER: Qiu H
PROVIDER: S-EPMC7035285 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response.
Qiu Huan H Jin Bang-Ming BM Wang Zhan-Feng ZF Xu Bin B Zheng Qi-Fan QF Zhang Li L Zhu Ling-Yu LY Shi Shuang S Yuan Jun-Bo JB Lin Xiao X Gao Shu-Bin SB Jin Guang-Hui GH
Nature communications 20200221 1
The MEN1 gene, a tumor suppressor gene that encodes the protein menin, is mutated at high frequencies in neuroendocrine (NE) tumors; however, the biological importance of this gene in NE-type lung cancer in vivo remains unclear. Here, we established an ATII-specific Kras<sup>G12D/+</sup>/Men1<sup>-/-</sup> driven genetically engineered mouse model and show that deficiency of menin results in the accumulation of DNA damage and antagonizes oncogenic Kras-induced senescence and the epithelial-to-me ...[more]
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