Ontology highlight
ABSTRACT:
SUBMITTER: Tursi SA
PROVIDER: S-EPMC7035420 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Tursi Sarah A SA Puligedda Rama Devudu RD Szabo Paul P Nicastro Lauren K LK Miller Amanda L AL Qiu Connie C Gallucci Stefania S Relkin Norman R NR Buttaro Bettina A BA Dessain Scott K SK Tükel Çagla Ç
Nature communications 20200221 1
Bacterial biofilms, especially those associated with implanted medical devices, are difficult to eradicate. Curli amyloid fibers are important components of the biofilms formed by the Enterobacteriaceae family. Here, we show that a human monoclonal antibody with pan-amyloid-binding activity (mAb 3H3) can disrupt biofilms formed by Salmonella enterica serovar Typhimurium in vitro and in vivo. The antibody disrupts the biofilm structure, enhancing biofilm eradication by antibiotics and immune cell ...[more]