Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC7035559 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Huang Yan Y Sun Lu L Pierrakeas Leonidas L Dai Linchang L Pan Lu L Luk Ed E Zhou Zheng Z
Proceedings of the National Academy of Sciences of the United States of America 20200130 7
The SWR complex edits the histone composition of nucleosomes at promoters to facilitate transcription by replacing the two nucleosomal H2A-H2B (A-B) dimers with H2A.Z-H2B (Z-B) dimers. Swc5, a subunit of SWR, binds to A-B dimers, but its role in the histone replacement reaction was unclear. In this study, we showed that Swc5 uses a tandem DEF/Y motif within an intrinsically disordered region to engage the A-B dimer. A 2.37-Å X-ray crystal structure of the histone binding domain of Swc5 in comple ...[more]