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Lysosomal Abnormalities in Cardiovascular Disease.


ABSTRACT: The lysosome, a key organelle for cellular clearance, is associated with a wide variety of pathological conditions in humans. Lysosome function and its related pathways are particularly important for maintaining the health of the cardiovascular system. In this review, we highlighted studies that have improved our understanding of the connection between lysosome function and cardiovascular diseases with an emphasis on a recent breakthrough that characterized a unique autophagosome-lysosome fusion mechanism employed by cardiomyocytes through a lysosomal membrane protein LAMP-2B. This finding may impact the development of future therapeutic applications.

SUBMITTER: Chi C 

PROVIDER: S-EPMC7036830 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Lysosomal Abnormalities in Cardiovascular Disease.

Chi Congwu C   Riching Andrew S AS   Song Kunhua K  

International journal of molecular sciences 20200127 3


The lysosome, a key organelle for cellular clearance, is associated with a wide variety of pathological conditions in humans. Lysosome function and its related pathways are particularly important for maintaining the health of the cardiovascular system. In this review, we highlighted studies that have improved our understanding of the connection between lysosome function and cardiovascular diseases with an emphasis on a recent breakthrough that characterized a unique autophagosome-lysosome fusion  ...[more]

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