Ontology highlight
ABSTRACT:
SUBMITTER: Choi EJ
PROVIDER: S-EPMC7037153 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Choi Eun-Jeong EJ Choi Go-Wun GW Kim Ju Hee JH Jang Hee-Woon HW Lee Ju-Hee JH Bae Hyun Ju HJ Kim Young Gwan YG Lee Yong-Bok YB Cho Hea-Young HY
Molecules (Basel, Switzerland) 20200204 3
Age-related macular degeneration (AMD) is wearing down of macula of retina, causing a blur or loss of vision in the center of the visual field. It can be categorized into dry or wet AMD. Until now, medical treatments for dry AMD have not been developed yet. The aim of this study was to evaluate pharmacokinetics (PKs) and tissue distribution of CK41016, a novel candidate for dry AMD, after intravenous (IV) or eye drop administration in rats and rabbits. In addition, a simple and sensitive bioanal ...[more]