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Chemical and Light Inducible Epigenome Editing.

ABSTRACT: The epigenome defines the unique gene expression patterns and resulting cellular behaviors in different cell types. Epigenome dysregulation has been directly linked to various human diseases. Epigenome editing enabling genome locus-specific targeting of epigenome modifiers to directly alter specific local epigenome modifications offers a revolutionary tool for mechanistic studies in epigenome regulation as well as the development of novel epigenome therapies. Inducible and reversible epigenome editing provides unique temporal control critical for understanding the dynamics and kinetics of epigenome regulation. This review summarizes the progress in the development of spatiotemporal-specific tools using small molecules or light as inducers to achieve the conditional control of epigenome editing and their applications in epigenetic research.

SUBMITTER: Zhao W

PROVIDER: S-EPMC7037166 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Chemical and Light Inducible Epigenome Editing.

Zhao Weiye W Wang Yufan Y Liang Fu-Sen FS

International journal of molecular sciences 20200203 3

The epigenome defines the unique gene expression patterns and resulting cellular behaviors in different cell types. Epigenome dysregulation has been directly linked to various human diseases. Epigenome editing enabling genome locus-specific targeting of epigenome modifiers to directly alter specific local epigenome modifications offers a revolutionary tool for mechanistic studies in epigenome regulation as well as the development of novel epigenome therapies. Inducible and reversible epigenome e ...[more]

PMID: 32028669

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