Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC7037257 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200101 1
Core 1-derived mucin-type O-glycans (O-glycans) are a major component of gastric mucus with an unclear role. To address this, we generated mice lacking gastric epithelial O-glycans (GEC C1galt1-/-). GEC C1galt1-/- mice exhibited spontaneous gastritis that progressed to adenocarcinoma with ∼80% penetrance by 1 yr. GEC C1galt1-/- gastric epithelium exhibited defective expression of a major mucus forming O-glycoprotein Muc5AC relative to WT controls, which was associated with impaired gastric acid ...[more]