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Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia.

ABSTRACT: This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity.

SUBMITTER: Aimond A

PROVIDER: S-EPMC7037520 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Cytotoxic and Anti-Inflammatory Effects of Ent-Kaurane Derivatives Isolated from the Alpine Plant Sideritis hyssopifolia.

Aimond Axelle A Calabro Kevin K Audoin Coralie C Olivier Elodie E Dutot Mélody M Buron Pauline P Rat Patrice P Laprévote Olivier O Prado Soizic S Roulland Emmanuel E Thomas Olivier P OP Genta-Jouve Grégory G

Molecules (Basel, Switzerland) 20200129 3

This paper reports the isolation and structural characterization of four new ent-kaurane derivatives from the Lamiaceae plant Sideritis hyssopifolia. Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compoun ...[more]

PMID: 32013210

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