Ontology highlight
ABSTRACT:
SUBMITTER: Canault M
PROVIDER: S-EPMC7037602 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Canault Matthias M Alessi Marie-Christine MC
International journal of molecular sciences 20200206 3
RasGRP2 is calcium and diacylglycerol-regulated guanine nucleotide exchange factor I that activates Rap1, which is an essential signaling-knot in "inside-out" αIIbβ3 integrin activation in platelets. Inherited platelet function disorder caused by variants of RASGRP2 represents a new congenital bleeding disorder referred to as platelet-type bleeding disorder-18 (BDPLT18). We review here the structure of RasGRP2 and its functions in the pathophysiology of platelets and of the other cellular types ...[more]