Ontology highlight
ABSTRACT:
SUBMITTER: Conte R
PROVIDER: S-EPMC7038067 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Conte Raffaele R Valentino Anna A Di Cristo Francesca F Peluso Gianfranco G Cerruti Pierfrancesco P Di Salle Anna A Calarco Anna A
International journal of molecular sciences 20200129 3
MicroRNAs (miRNAs) play a pivotal role in regulating the expression of genes involved in tumor development, invasion, and metastasis. In particular, microRNA-124 (miR-124) modulates the expression of carnitine palmitoyltransferase 1A (CPT1A) at the post-transcriptional level, impairing the ability of androgen-independent prostate cancer (PC3) cells to completely metabolize lipid substrates. However, the clinical translation of miRNAs requires the development of effective and safe delivery system ...[more]