Ontology highlight
ABSTRACT:
SUBMITTER: Amick J
PROVIDER: S-EPMC7039192 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Amick Joseph J Tharkeshwar Arun Kumar AK Talaia Gabriel G Ferguson Shawn M SM
The Journal of cell biology 20200101 1
The C9orf72 protein is required for normal lysosome function. In support of such functions, C9orf72 forms a heterotrimeric complex with SMCR8 and WDR41 that is recruited to lysosomes when amino acids are scarce. These properties raise questions about the identity of the lysosomal binding partner of the C9orf72 complex and the amino acid-sensing mechanism that regulates C9orf72 complex abundance on lysosomes. We now demonstrate that an interaction with the lysosomal cationic amino acid transporte ...[more]