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Structural and genetic diversity in antibody repertoires from diverse species.

ABSTRACT: The antibody repertoire is the fundamental unit that enables development of antigen specific adaptive immune responses against pathogens. Different species have developed diverse genetic and structural strategies to create their respective antibody repertoires. Here we review the shark, chicken, camel, and cow repertoires as unique examples of structural and genetic diversity. Given the enormous importance of antibodies in medicine and biological research, the novel properties of these antibody repertoires may enable discovery or engineering of antibodies from these non-human species against difficult or important epitopes.

SUBMITTER: de los Rios M

PROVIDER: S-EPMC7039331 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Structural and genetic diversity in antibody repertoires from diverse species.

de los Rios Miguel M Criscitiello Michael F MF Smider Vaughn V VV

Current opinion in structural biology 20150717

The antibody repertoire is the fundamental unit that enables development of antigen specific adaptive immune responses against pathogens. Different species have developed diverse genetic and structural strategies to create their respective antibody repertoires. Here we review the shark, chicken, camel, and cow repertoires as unique examples of structural and genetic diversity. Given the enormous importance of antibodies in medicine and biological research, the novel properties of these antibody ...[more]

PMID: 26188469

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