Ontology highlight
ABSTRACT:
SUBMITTER: Gray MW
PROVIDER: S-EPMC7039547 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20200117 8
The ribosome and RNase P are cellular ribonucleoprotein complexes that perform peptide bond synthesis and phosphodiester bond cleavage, respectively. Both are ancient biological assemblies that were already present in the last universal common ancestor of all life. The large subunit rRNA in the ribosome and the RNA subunit of RNase P are the ribozyme components required for catalysis. Here, we explore the idea that these two large ribozymes may have begun their evolutionary odyssey as an assembl ...[more]