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Fetuin-A and fetal growth in gestational diabetes mellitus.


ABSTRACT: OBJECTIVE:Fetuin-A is a glycoprotein produced by hepatocytes and has been associated with insulin resistance and bone growth in postnatal life. Gestational diabetes mellitus (GDM) is a condition characterized by insulin resistance. It is unclear whether GDM may affect cord blood fetuin-A levels and whether fetuin-A is associated with fetal growth. RESEARCH DESIGN AND METHODS:In a nested case-control study of 153 matched pairs of neonates of mothers with GDM and euglycemic pregnancies in the Shanghai Birth Cohort, we evaluated cord blood fetuin-A in association with GDM and fetal growth. RESULTS:Comparing the newborns of GDM versus euglycemic mothers, cord blood fetuin-A concentrations were similar (mean±SD: 783.6±320.0 vs 754.8±281.9?µg/mL, p=0.53), while insulin-like growth factor (IGF)-I (76.6±27.8?ng/mL vs 68.1±25.1?ng/mL, p=0.008) and IGF-II (195.3±32.5?ng/mL vs 187.5±30.8?ng/mL, p=0.042) concentrations were higher. Cord blood fetuin-A was not correlated with insulin, IGF-I or IGF-II. Cord blood fetuin-A was negatively correlated with birth weight (r=-0.19, p=0.025) and birth length (r=-0.24, p=0.005) z scores in GDM pregnancies, while there were no significant correlations in euglycemic pregnancies (tests for interaction: p=0.014 for birth length, p=0.013 for birth length). Adjusting for maternal and neonatal characteristics, the differential associations remained. CONCLUSIONS:GDM was not associated with cord blood fetuin-A levels. Fetuin-A was negatively associated with fetal growth in GDM but not in euglycemic pregnancies. This novel observation suggests a GDM-conditional negative correlation of fetuin-A with fetal growth.

SUBMITTER: Wang WJ 

PROVIDER: S-EPMC7039609 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Fetuin-A and fetal growth in gestational diabetes mellitus.

Wang Wen-Juan WJ   Zhang Lin L   Zheng Tao T   Zhang Guang-Hui GH   Du Kun K   Yang Meng-Nan MN   He Hua H   Wang Shufan S   Wang Weiye W   Zhang Jun J   Ouyang Fengxiu F   Luo Zhong-Cheng ZC  

BMJ open diabetes research & care 20200201 1


<h4>Objective</h4>Fetuin-A is a glycoprotein produced by hepatocytes and has been associated with insulin resistance and bone growth in postnatal life. Gestational diabetes mellitus (GDM) is a condition characterized by insulin resistance. It is unclear whether GDM may affect cord blood fetuin-A levels and whether fetuin-A is associated with fetal growth.<h4>Research design and methods</h4>In a nested case-control study of 153 matched pairs of neonates of mothers with GDM and euglycemic pregnanc  ...[more]

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